Standardization of drying and extraction techniques for better colchicine recovery from Gloriosa superb
نویسندگان
چکیده
Gloriosa superba is a very important medicinal plant that is used for the treatment of diseases like Gout, arthritis, cancer and act as anthelmintic, antimitotic and antiabortive agent. Its tuber is a great source of Colchicine for the pharmaceutical industries and requires drying before extraction. The accelerated artificial drying technique using Microwave Vacuum oven was evaluated with other methods using different extraction & purification for Colchicine by performing High Performance Liquid Chromatography (HPLC). It was observed that the recovery of Colchicine from extracts prepared by Soxhlet method were greater than that of Sonicator likewise, colchicine content in extract of Microwave Vacuum Dried Tuber was greater as compared to the Hot Air Oven Dried Tuber. This study is useful for Pharmaceutical industries for extracting colchicine using accelerated drying techniques like microwave vacuum oven economically and in less time consuming manner.
منابع مشابه
Optimization of extraction conditions for colchicine from Gloriosa superba tubers using response surface methodology
Gloriosa superba is a medicinal plant used in traditional medicine for the treatment of various diseases. The tuber of Gloriosa superba is a rich source of colchicine which is used for the treatment of gout, cirrhosis and also used in plant breeding studies to produce polyploidy. Optimization of various extraction parameters using response surface methodology (RSM) was performed to assess maxim...
متن کاملAcute fulminant hepatic failure due to colchicine – a rare manifestation of Gloriosa superba poisoning.
متن کامل
Quantification of Colchicine in Seed and Tuber samples of Gloriosa superba by High Performance Liquid Chromatography method
To quantify the colchicine (alkaloid) present in Gloriosa superba by High Performance Liquid Chromatography (HPLC) method. Gloriosa superba species are known for their content of colchicine, a valuable alkaloid in the seeds and tubers (corms). HPLC analysis was carried out to confirm the presence of colchicine in Gloriosa superba. Treatment of gibberellic acid and Psedomonas aerugenosa improved...
متن کاملImproved growth and colchicine concentration in Gloriosa superba on mycorrhizal inoculation supplemented with phosphorus-fertilizer.
BACKGROUND Gloriosa superba produces an array of alkaloids including colchicine, a compound of interest in the treatment of various diseases. The tuber of Gloriosa superba is a rich source of colchicine which has shown anti-gout, anti-inflammatory, and anti-tumor activity. However, this promising compound remains expensive and Gloriosa superba is such a good source in global scale. Increase in ...
متن کاملEvaluation of factors affecting on lipid extraction for recovery of fatty acids from Nannochloropsis oculata micro-algae to biodiesel production
Background: This study aimed at determining the appropriate method for dewatering and drying biomass and selecting a suitable organic solvent for lipid extraction. Methods: Nannochloropsis Oculata was cultured in Gillard F/2 medium and after reaching the end of the stationary growth phase, algal biomass was separated from aqueous by centrifuge and dried through three methods: Oven, Air-dried an...
متن کامل